The Definitive Guide to ceesdekker
The Definitive Guide to ceesdekker
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‘The next is nanopores, that's our oldest line of exploration and that has now brought about DNA sequencers based upon nanopores. We pull particular person DNA strands via a nanopore and might then read through off the nucleotide sequence. Really just lately, we even managed to read through out an individual protein for The very first time making use of this technique. But this line of analysis is not just about developing applications, but will also about authentic biological concerns.
It had been only during the nineties nevertheless, when nanotechnology had Highly developed to some level the place one molecules could possibly be manipulated, that the main experimental units commenced to appear.
‘It had been just a make a difference of selecting up a e-book on cell biology and beginning to go through. I had originate from a entire world of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Functioning at space temperature with molecular biology kits.
Non-equilibrium folding of particular person DNA molecules recaptured as many as one thousand occasions in the solid condition nanopore
2010, made a new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by way of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into solid-state nanopores
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en fulfilled 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
Duration Charge of particular person carbon nanotubes by nanostructuring Along with the scanning tunneling microscope
2000, discovery that nanotubes can carry incredible big latest densities; resolved the controversial situation of Digital transport by way of DNA molecules by measurements of insulating behavior at The only molecule stage; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
Knowing elementary processes regulating the spatial and dynamic organisation on the DNA in Dwell cells.
‘The fantastically refined way where aspects in character perform by no means ceases to amaze me. If we solve the puzzle of how everyday living arrived into getting, I anticipate that my amazement at the complexity of generation could have improved and with it my awe for the greatness of your Creator.’
Because 2000 he moved to one-molecule biophysics and nanobiology, with analysis from research of DNA loop extrusion and supercoiling to DNA translocation as a result of nanopores. Far more not too long ago his investigation has centered on studying chromatin framework and cell division with micro organism on chip, whilst he is usually trying to ultimately Create artificial cells from the bottom up.
Cees Dekker is Distinguished College Professor at TU Delft. Trained as a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes in the 1990s. Since 2000, he moved to one-molecule biophysics and nanobiology. His current research concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, specifically SMC motor protein; and (iii) creating a dwelling artificial cell from lifeless molecules. Dekker is surely an elected member in the KNAW and fellow towards the APS and also the IOP.
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Instance (two) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim https://www.ceesdekker.net from the pore is highlighted in pink, plus a 3D rendering from the movement of the DNA rod is shown.